Why athletes should avoid taking any medications containing PSE during competition

Posted on January 25, 2014 by Stone Hearth News

Int J Sport Nutr Exerc Metab. 2014 Jan 17. [Epub ahead of print]

Hydration and Urinary Pseudoephedrine Levels After a Simulated Team Game.

Jolley D, Dawson B, Maloney SK, White J, Goodman C, Peeling P.

Author information School of Sport Science, Exercise, and Health, University of Western Australia, Crawley, Australia.

Abstract

This study investigated the influence of dehydration on urinary levels of pseudoephedrine (PSE) after prolonged repeated effort activity.

Fourteen athletes performed a simulated team game circuit (STGC) outdoors over 120 min under three different hydration protocols: hydrated (HYD), dehydrated (DHY) and dehydrated + post-exercise fluid bolus (BOL).

In all trials, a 60 mg dose of PSE was administered 30 min before each trial and at half time of the STGC. Urinary PSE levels were measured before drug administration and at 90 min post-exercise.

Additionally, body mass (BM) changes and urinary specific gravity (USG), osmolality (OSM), creatinine (Cr) and pH values were recorded.

No differences in PSE levels were found 90 min post-exercise between conditions (HYD: 208.5 ± 116.5; DHY: 238.9 ± 93.5; BOL: 195.6 ± 107.3 μg·ml-1), although large variations were seen within and between participants across conditions (range: 33 to 475 μg·ml-1: ICC r = 0.03-0.16, p>0.05).

There were no differences between conditions in USG, OSM, pH or PSE/Cr ratio.

In conclusion, hydration status did not influence urinary PSE levels after prolonged repeated effort activity, with ~70% of samples greater than the WADA limit (>150 μg·ml-1), and ~30% under.

Due to the unpredictability of urinary PSE values, athletes should avoid taking any medications containing PSE during competition.

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